Special Pathogens Research Network [Spparenet] Ltd

Abstract

Special Bacterial Pathogens Journal (SBPJ) 2015; Vol 1, No 1: p 0005-0009;  Copyright © Special Pathogens Research Network Limited, Uganda, All Rights Reserved

 1Odoki M, 2Bazira J, 3Moazam ML and 1Agwu E

1Department of Microbiology and Immunology, Kampala International University, Western Campus, Box 71, Bushenyi, Uganda. 2Department of Medical Microbiology, Mbarara University of Science and technology, Mbarara, Uganda. 3Department of Public Health, Kampala International University, Western Campus, Box 71, Bushenyi, Uganda.

Health-point survey of bacteria urinary tract infections among suspected diabetic patients attending clinics in Bushenyi district of Uganda

Abstract

Background: Although Urinary tract infections (UTI) and diabetes are individual public health pandemic, their comorbidities remain a global health dilemma. Regional surveillance holds the key for effective intervention. Objectives: To evaluate the prevalence and antibacterial resistance pattern of bacteria etiological agents of UTI among diabetic patients in Bushenyi district of Uganda. Methods: In this cross-sectional study, 418 midstream urine from consenting 331 diabetic (230 females and 101 males) and 87 non-diabetic (60 females and 27 males) individuals were collected aseptically and processed using standard microbiological methods. Data generated were tested for statistical significance and scientific relevance. Results: Bacteria UTI were 31.1% prevalent in diabetic and 11.4% in non-diabetics. Diabetic patients yielded: 13.6%, Staphylococcus species, 8.8% E.coli, and 8.6% Klebsiella species. Klebsiella species showed 100% resistance to Erythromycin, 71.4% to Cotrimoxazole, and 92.9% to Ampicillin. Bacteria from diabetic patients remained sensitive to: Nitrofurantoin, Ciprofloxacin, Ceftazidime and Ceftriaxone. Extended Spectrum β-Lactamases was detected in 3.5% of Klebsiella species. Age and sex significantly (p<0.05) influenced diabetic UTI prevalence. Conclusion: Diabetes significantly (p<0.05) influenced the observed (27%) UTI distribution. Resistance to Ampicillin and Cotrimoxazole may affect their use in UTI management. Antibacterial misuse is highly discouraged and Nitrofurantoin remains urinary antiseptic.

Key words:

Diabetic patients, Bacteria UTI, Bushenyi, Uganda

Corresponding Author:

Odoki Martin: Disease Intervention and Management Failure (DIMAF) research group, Department of Medical Microbiology, Faculty of Basic Medical Sciences, Kampala International University, Box 71, Bushenyi, Uganda. Mail: odokimartin@yahoo.co.uk