Special Fungal Pathogens Journal [SFPJ]

Abstract

Colonization and susceptibility profile of vaginal yeast isolates in

Ekpoma, Edo state Nigeria

 

Special Fungal Pathogens Journal (SFPJ) 2015; Vol 1, No 1: p 0007-0013;  Copyright © Special Pathogens Research Network Limited, Uganda, All Rights Reserved

 

1Inyang NJ, 2Enweani IB, 3Agwu E, 4Esumeh FI, 5Obiazi HAK, 6Eifediyi RA, 7Ikheloa J

 

1Microbiology Department, Irrua Specialist Teaching Hospital Irrua Edo State, Nigeria. 2Department of Medical Laboratory Sciences, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Nnewi campus Anambra state, Nigeria. 3Department of Microbiology, Kampala International University Western campus Ishaka Bushenyi, Uganda.4Microbiology Department, Faculty of Natural Sciences Ambrose Alli University Ekpoma,    Edo state, Nigeria. 5Department of Medical Laboratory Sciences, Ambrose Alli University, Ekpoma Edo State, Nigeria. 6&7Department of Obstetrics and Gynecology, Irrua Specialist Teaching Hospital, Irrua, Edo State Nigeria.

 

Abstract

Background: Although Candida albicans remains a persistent pathogen in humans, little is known about the relationship between commensal and infecting strains, the origins of infecting strains, transmission of the organism between individuals, and strain specialization. Objective: To outline the colonization profile and susceptibility to azoles of vaginal yeast isolates in Ekpoma, Nigeria. Methods: In this study, 300 vaginal swabs were aseptically collected from women visiting Hospitals in Ekpoma. Samples were processed phenotypically using standard mycological protocols. PCR was done on representative isolates whose identity could not be phenotypically ascertained. Minimum inhibitory Concentration for azoles were tested using E- test strip. Results: Candida albicans showed 22.3% prevalence followed by C. glabrata with 8.7% prevalence and both yeast showed dose dependent sensitivity to azoles. The married women aged 20-39 years (47.6% and 36.8%) were the most vulnerable followed by single asymptomatic women aged 10-19years. Nine per-cent aged 29, had no marital status. Married women showed high prevalence in all age groups while 40-29 (62.3%) showed the highest prevalence among singles. Among the symptomatic group, 33.3% aged 30-39 with secondary education and 13.3% of symptomatic patients aged 10-19years (13.3%) were most vulnerable. Among the asymptomatic participants 35.7% with primary education aged 40-49 were most vulnerable. Conclusions: Yeast prevalence in VVC may result from patient change in immune status and may not be affected by demographic and sociocultural factors. In-depth antifungal susceptibility testing is required to investigate if the routine use of antifungal drugs can lead to shifts in the colonization and susceptibility status of Candida species. .

Key words:

Vaginal yeast burden/susceptibility in Ekpoma

Corresponding Author:

Corresponding Author: Microbiology Department, Irrua Specialist Teaching Hospital Irrua Edo State, Nigeria. e-mail nyohoinyang@yahoo.com. TeL: +2348033724973 and +2348022109358

 

How to cite this article:

Inyang NJ, Enweani IB, Agwu E, Esumeh FI, Obiazi HAK, Eifediyi RA, Ikheloa J. Colonization and susceptibility profile of vaginal yeast isolates in Ekpoma, Edo state Nigeria. Special Fungal Pathogens Journal 2015, Vol 1, No 1: p 0007-0013